Formulation Development and Characterization of Targeted Drug Delivery System for Breast Cancer

Rajkumari Thagele, Mohan Lal Kori
Wheat; Six Parameter Models; Gene Effects
Cancer is one among the leading causes of death worldwide. Cancer cells proliferate at much faster rate than the normal cells. The available traditional cancer chemotherapy is not essentially selective as it depends on the kinetics of the cell growth.1Breast cancer is common lethal cause of malignancy among women around all the countries. Early detection of breast cancer facilitates the diagnosis and treatment prior to metastasis. Despite remarkable development in new medicine findings and therapies for carcinoma during previous decades, no significant treatment methods are accessible for cancer-affected people with invasive and metastatic carcinoma. During this stage, the patients have less response to cancer therapy thanks to recurrence properties of cancer.
[1] Jagadeesh G Hiremath, V Kusum Devi (2011). Preparation and in vitro characterization of poly(epsilon-caprolactone)-based tamoxifen citrate-loaded cylindrical subdermal implant for breast cancer. Asian journal of pharmaceutical sciences: 9-14.
[2] Jun H.Lee and Anjan Nan (2012). Combination of drug delivery approaches in metastatic Breast Cancer. Jou. of Drug Delivery. 1-17.
[3] Mali Deeapak, Nanjwade Basavaraj, Manvi F.V. (2013). Formulation and charactertization of Tamoxifen loaded stealth lipososmes for breast cancer. International Journal of Drug Development and Research. 5 (1):271-278.
[4] Naif Abdullah Al-Dhabi, (2016) Srisesharam Srigopalram,Soundharrajan Ilavenil,Young Ock Kim, Paul Agastian, Rajasekhar Baaru, Kannan Balamurugan, Ki Choon Choi, and Mariadhas Valan Arasu Proteomic Analysis of Stage-II Breast Cancer from Formalin-Fixed Paraffin-Embedded Tissues. BioMed Research International. Volume.1-6.
[5] Navneet Sharma, Parshotam Madan, Senshang Lin (2016) Effect of process and formulation variables on the preparation of parenteral paclitaxel-loaded biodegradable polymeric nanoparticles : A co-surfactant study. Asian L. of pharmaceutical sciences 11: 404–416.
[6] Özgür Erdem1 and Ezzettin Tokta G .Knowledge, Attitudes, and Behaviors about Breast Self-Examination and Mammography among Female Primary Healthcare Workers in DiyarbakJr, Turkey. BioMed Research International.1-6.
[7] P. Convreur (2013). Nanoparticles in drug delivery: Past, Present and Future.Advanced Drug Delivery Reviews.65: 21-23.
[8] Prajna Mishra, Bismita Nayak, R.K. Dey (2016). PEGylation in anti-cancer therapy: An overview. Asian journal of pharmaceutical sciences 11: 337–348.
[9] Rajath Othayoth1 K. Santhosh Kumar2 & Varshini Karthik (2013). Development and Characterization of Chitosan-Pluronic Polymeric Nanoparticles for the Breast Cancer Treatment. International Journal on Mechanical Engineering and Robotics. Volume-1(1):71-79.
[10] Sanjeev R. Acharya a, Padmanabha R.V. Reddy (2016). Brain targeted delivery of paclitaxel using endogenous ligand. Asian journal of pharmaceutical sciences 11:427–438.

Received : 14 January 2020
Accepted : 10 July 2020
Published : 26 July 2020
DOI: 10.30726/esij/v7.i3.2020.73015