Assessment of Viral Suppression among HIV Seropositive Adults on Dolutegravir-Based Regimen in Federal Medical Centre Owerri, Nigeria

S. Ogbaji, C.I.C Ebirim, U.W Dozie and A.D. Oguizu
HIV/AIDS; Viral Load Suppression; Dolutegravir-based Regimen; Federal Medical Centre Owerri; Nigeria.
Introduction: In Nigeria, the majority of patients on antiretroviral therapy are on dolutegravir-based regimens which are the result of the massive transition of patients from non-dolutegravir-based regimens to dolutegravir-based regimens. This study assessed the effectiveness of dolutegravir-based regimens in suppressing viral load in HIV seropositive adults in comparison to non-dolutegravir-based regimens.
Methods: A retrospective cohort study design was used to assess the viral loads of 385 patients accessing HIV care and treatment at Federal Medical Centre Owerri. Subjects were selected using a simple random sampling method. Data was analysed using IBM-SPSS statistics version 25, statistical charts were drawn on Microsoft Excel 16. Descriptive statistician technique (Frequency distribution) was also used. T distribution test technique for paired samples and descriptive technique were used accordingly.
Results: The result of the study shows that 96.4% of patients on dolutegravir-based regimens have a viral load of less than1000 copies/ml as against 70.4% when these patients were on dolutegravir-based regimens. Participants with poor adherence, which is less than 95%, recorded a lower suppression rate (83.6%) than those with good adherence, which recorded 99.1% suppression. Similarly, the viral load suppression rate was higher among the patients without disease co-morbidity (98.9%) compared to the co-morbidity group (89.2%).
Conclusion: The study shows that 96.4% of adults accessing HIV treatment at FMC Owerri and on first-line regimens are virally suppressed.
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Received :26February2023
Accepted :18June2023
Published :27June2023
DOI: 10.30726/esij/v10.i2.2023.102001