Sleep-Disordered Breathing Advances in Diagnostic Modalities, Pathophysiological Insights, and Multidisciplinary Therapeutic Strategies

Author
Dr. Shubham Mithal, Sangeeta Sharma, Ajay Kumar
Keywords
Sleep-Disordered Breathing; Obstructive Sleep Apnea; Polysomnography; Sleep Medicine; Respiratory Sleep Disorders; Sleep Diagnostics.
Abstract
Sleep-disordered breathing (SDB) represents a spectrum of respiratory disturbances occurring during sleep, including obstructive sleep apnea, central sleep apnea, and hypoventilation syndromes. These conditions are associated with repeated episodes of airflow limitation, oxygen desaturation, and sleep fragmentation, significantly impairing cardiovascular, neurological, and metabolic health. Sleep-disordered breathing has become a major global health concern due to its high prevalence and strong association with chronic conditions such as hypertension, cardiac arrhythmias, obesity, and metabolic syndrome. This cross-sectional analytical study examines contemporary diagnostic approaches and therapeutic strategies used in the management of SDB among 226 patients. Polysomnography remains the gold standard diagnostic method, although home-based sleep monitoring technologies and wearable diagnostic devices are increasingly used. Continuous positive airway pressure therapy demonstrated the most effective treatment outcomes (F=7.45, p=0.001) in patients with moderate to severe obstructive sleep apnea. Behavioural therapy interventions, weight management programmes, and surgical interventions also contributed to improved clinical outcomes in selected patient groups.
References
[1] . Abad, V. C., & Guilleminault, C. (2003). Diagnosis and treatment of sleep disorders: a brief review for clinicians. Dialogues in Clinical Neuroscience, 5(4), 371–388.
[2] Bruyneel, M., & Ninane, V. (2014). Unattended home-based polysomnography for sleep disordered breathing. Sleep Medicine Reviews, 18(4), 341–347.
[3] Foldvary-Schaefer, N. R., & Waters, T. E. (2017). Sleep-disordered breathing. CONTINUUM: Lifelong Learning in Neurology, 23(4), 1093–1116.
[4] Gozal, D., & Kheirandish-Gozal, L. (2010). New approaches to the diagnosis of sleep-disordered breathing in children. Sleep Medicine, 11(7), 708–713.
[5] Gurbani, N., et al. (2021). Sleep disordered breathing: Assessment and therapy in the age of emerging neuromuscular therapies. Pediatric Pulmonology, 56(4), 700–709.
[6] Haynes, P. L. (2005). The role of behavioral sleep medicine in the assessment and treatment of sleep disordered breathing. Clinical Psychology Review, 25(5), 673–705.
[7] Linz, D., et al. (2018). Assessment and interpretation of sleep disordered breathing severity in cardiology. International Journal of Cardiology, 271, 281–288.
[8] Mehra, R., et al. (2022). Sleep-disordered breathing and cardiac arrhythmias in adults. Circulation, 146(9), e119–e136.
[9] Pack, A. I. (2006). Advances in sleep-disordered breathing. American Journal of Respiratory and Critical Care Medicine, 173(1), 7–15.
[10] Pinilla, L., et al. (2025). Diagnostic Modalities in Sleep Disordered Breathing: Current and Emerging Technology. Respirology, 30(4), 286–302.
[11] Randerath, W., et al. (2018). Challenges and perspectives in obstructive sleep apnoea. European Respiratory Journal, 52(3).
[12] Randerath, W., et al. (2017). Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep. European Respiratory Journal, 49(1).
[13] Thurnheer, R. (2011). Diagnostic approach to sleep-disordered breathing. Expert Review of Respiratory Medicine, 5(4), 573–589.
[14] Truong, K. K., & Guilleminault, C. (2018). Sleep disordered breathing in pregnant women. Expert Review of Respiratory Medicine, 12(3), 177–189.
[15] Arockia, V. J., Vettriselvan, R., Rajesh, D., Velmurugan, P. R. R., & Cheelo, C. (2025). Leveraging AI and Learning analytics for enhanced distance learning: transformation in education. In AI and learning analytics in distance learning (pp. 179-206). IGI Global Scientific Publishing.
[16] Ashifa, K. M. (2019). Developmental initiatives for persons with disabilities: Appraisal on village-based rehabilitation of Amar Seva Sangam. Indian Journal of Public Health Research & Development, 10(12), 1257–1261.
[17] Rasi, R. A., & Ashifa, K. M. (2019). Role of community-based programmes for active ageing: Elders self-help group in Kerala. Indian Journal of Public Health Research & Development, 10(12).
[18] Ashifa, K. M. (2020). Effect of substance abuse on physical health of adolescents. European Journal of Molecular & Clinical Medicine, 7(2), 3155–3160.
[19] Ashifa, K. M. (2020). Physical health hazards of schizophrenia patients. Systematic Reviews in Pharmacy, 11(12), 1848–1850.
[20] Ashifa, K. M. (2021). Analysis on the determinants of health status among tribal communities. Journal of Cardiovascular Disease Research, 12(3), 531–534.
[21] Ashifa, K. M. (2021). Health status of primitive tribal women in India. Journal of Cardiovascular Disease Research, 12(5), 772.
[22] Ashifa, K. M. (2022). A situation analysis of the social well-being of elderly during the COVID-19 pandemic. International Journal of Health Sciences, 6(3), 10156–10163.
[23] Ashifa, K. M., & Ramya, P. (2019). Health afflictions and quality of work life among women working in fireworks industry. International Journal of Engineering and Advanced Technology, 8(6S3), 1723–1725.
[24] Basha, R., Pathak, P., Sudha, M., Soumya, K. V., & Arockia Venice, J. (2025). Optimization of quantum dilated convolutional neural networks: Image recognition with quantum computing. Internet Technology Letters, 8(3), e70027.
[25] Catherine, S., Gupta, N., Gopi, E., & Swadhi, R. (2025). Enhancing Patient Engagement and Outcomes Through Digital Transformation: Machine Learning in Medical Marketing. In Impact of Digital Transformation on Business Growth and Performance (pp. 285-312). IGI Global Scientific Publishing.
[26] Devi, M., Manokaran, D., Sehgal, R. K., Shariff, S. A., & Vettriselvan, R. (2025). Precision Medicine, Personalized Treatment, and Network-Driven Innovations: Transforming Healthcare With AI. In AI for Large Scale Communication Networks (pp. 303-322). IGI Global Scientific Publishing.
[27] Elkin, N., Mohammed, A. K., Kilincel, S., Soydan, A. M., Tanriver, S. C., Celik, S., & Ranganathan, M. (2025). Mental health literacy and happiness among university students: A social work perspective to promoting well-being. Frontiers in Psychiatry, 16, 1541316.
[28] Gayathri, R. K., Vettriselvan, R., Rajesh, D., Balakrishnan, R., Kumar, R., & Kavitha, J. (2025). Striking a Balance: Mental Health Challenges and Work-Life Integration among Women Faculty in Indian B-Schools. Texila International Journal of Public Health, 13(2).
[29] Gayathri, R. K., Vettriselvan, R., Rajesh, D., Balakrishnan, R., Kumar, R., & Kavitha, J. (2025). Strategic Role of Human Resource Management in Enhancing Occupational Health and Safety Practices in Business Schools in India. Texila International Journal of Public Health, 13(2).
[30] Jenifer, R. D., Vettriselvan, R., Saxena, D., Velmurugan, P. R., & Balakrishnan, A. (2025). Green Marketing in Healthcare Advertising: A Global Perspective. In AI Impacts on Branded Entertainment and Advertising (pp. 303-326). IGI Global Scientific Publishing.
[31] Kariveliparambil, A., Rasi, R. A., Ahmad, M. S., Oztas, N., & Ayan, F. S. (2026). Evolving Social Capital in Indigenous Communities: Perspectives on Trust, Reciprocity, and Cultural Preservation Among Irula Elders. Journal of Social Service Research, 52(1), 147–166.
[32] Mustafa, N., Zahoor, H., Gamil, R. E., Ashifa, K. M., & Safaei, M. (2026). Empowering future caregivers: the role of self-leadership in reducing stress among nursing students. International Journal of Innovation and Learning, 39(1), 74-103.
[33] Natraj, N. A., Abirami, T., Ananthi, K., Venice, J. A., Chandru, R., & Rathish, C. R. (2024). The Impact of 5G Technology on the Digital Supply Chain and Operations Management Landscape. In Applications of New Technology in Operations and Supply Chain Management (pp. 289-311). IGI Global Scientific Publishing.
[34] Ranganathan, M., Jacob, A., Ashifa, K. M., Kumar, G. J., Anthony, M., Vijay, M., & Kumari, R. B. (2024). An investigation of the effects of chronic stress on attention in parents of children with neurodevelopmental disorders. Universal Journal of Public Health, 12(1), 37–50.
[35] Shanthi, H. J., Gokulakrishnan, A., Sharma, S., Deepika, R., & Swadhi, R. (2025). Leveraging Artificial Intelligence for Enhancing Urban Health: Applications, Challenges, and Innovations. In Nexus of AI, Climatology, and Urbanism for Smart Cities (pp. 275-306). IGI Global Scientific Publishing.
[36] Swadhi, R., Gayathri, K., Suresh, N. V., Catherine, S., & Velmurugan, P. R. (2025). Leveraging Machine Learning for Enhanced Patient Engagement and Outcomes: Revolutionizing Healthcare Marketing. In Impact of Digital Transformation on Business Growth and Performance (pp. 313-340). IGI Global Scientific Publishing.
[37] Swadhi, R., Velmurugan, P. R., Mahalingam, U., Keerthana, R., & Padmavathy, N. (2026). Embedding Fairness and Resilience: Human-Centered Leadership in AI-Driven Workplaces. In Centering Positive Organizational Cultures Through Human-Centered Leadership (pp. 139-162). IGI Global Scientific Publishing.
[38] Venice, J. A., Arivazhagan, D., Suman, N., Shanthi, H. J., & Swadhi, R. (2025). Recommendation systems and content personalization: algorithms, applications, and adaptive learning. In AI for Large Scale Communication Networks (pp. 323-348). IGI Global Scientific Publishing.
[39] Venice, J. A., Vettriselvan, R., Rajesh, D., Suresh, N. V., & Abirami, P. (2025). Enabling personalized learning and adaptive systems through strategic management: cloud integration in education. In Bridging Academia and Industry Through Cloud Integration in Education (pp. 49-72). IGI Global Scientific Publishing.
[40] Venice, J. A., Vettriselvan, R., Jain, S., Madusudanan, K., & Aarthy, C. C. J. (2025). Performance Evaluation and Metrics in Blockchain Powered AI/ML: Data Analytics for Cognitive Internet of Things (CIoT). In Transforming Education With AI-Powered Personalized Learning (pp. 143-178). IGI Global Scientific Publishing.
[41] Venice, A., Swadhi, R., Gayathri, K., Chandra, P., & Sajana, K. P. (2026). Rehabilitation Robotics and Adaptive Motion Planning for Patient-Centric Care. In Intelligent Motion Control for Human-Centered Systems (pp. 51-76). IGI Global Scientific Publishing.
[42] Vettriselvan, R. (2025). Harnessing innovation and digital marketing in the era of industry 5.0: resilient healthcare SMEs. In The Future of Small Business in Industry 5.0 (pp. 163-186). IGI Global Scientific Publishing.
[43] Vettriselvan, R., & Anto, M. R. (2018). Pathetic health status and working condition of Zambian women. Indian Journal of Public Health Research & Development, 9(9), 259-264.
[44] Vettriselvan, R., & Rajan FSA, A. J. (2019). Occupational Health Issues Faced by Women in Spinners. Indian Journal of Public Health Research & Development, 10(1).
[45] Vettriselvan, R., Deepan, A., Jaiswani, G., Balakrishnan, A., & Sakthivel, R. (2025). Health Consequences of Early Marriage: Examining Morbidity and Long-Term Wellbeing. In Social, Political, and Health Implications of Early Marriage (pp. 189-212). IGI Global Scientific Publishing.
[46] Vettriselvan, R., Ramya, R., Selvalakshmi, V., Jyothi, P., & Velmurugan, P. R. (2026). Empowering Patients through Knowledge: Educational Strategies in Rehabilitation. In Holistic Approaches to Health Recovery (pp. 263-290). IGI Global Scientific Publishing.
[47] Vijayalakshmi, M., Subramani, A. K., Vettriselvan, R., Catherin, T. C., & Deepika, R. (2025). Sustainability and Responsibility in the Digital Era: Leveraging Green Marketing in Healthcare. In Digital Citizenship and Building a Responsible Online Presence (pp. 285-306). IGI Global Scientific Publishing.
[48] Vijayalakshmi, M., Subramani, A. K., Vettriselvan, R., Velmurugan, P. R., & Hasine, J. (2025). Strategic Collaborations in Medical Innovation and AI-Driven Globalization: Advancing Healthcare Startups. In Navigating Strategic Partnerships for Sustainable Startup Growth (pp. 85-110). IGI Global Scientific Publishing.
[49] Zahoor, H., Mustafa, N., Ashifa, K. M., Safaei, M., & El Gamil, R. (2025). Unlocking resilience: Emotional intelligence and self-leadership shape stress perception among health students. International Journal of Innovation and Learning, 38(4), 395–419.

Received : 08 February 2026
Accepted : 26 April 2026
Published : 28 April 2026
DOI: 10.30726/ijmrss/v13.i2.2026.13236

36.-66_Sleep_Disordered_Breathing.pdf